🧬 Key Functions and Mechanisms
Activates AMPK Pathway: MOTS-C stimulates AMP-activated protein kinase, a master regulator of cellular energy homeostasis.
Enhances Insulin Sensitivity: Particularly in skeletal muscle, improving glucose uptake and metabolic efficiency.
Promotes Fat Utilization: Encourages the body to burn fat for energy, especially under metabolic stress.
Supports Mitochondrial Function: Helps maintain energy balance during aging, exercise, and caloric restriction.
Regulates Nuclear Gene Expression: Translocates to the nucleus to influence genes involved in antioxidant defense and metabolism